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Adults—At first, 400 milligrams (mg). obat glibenclamide 5 mg A second dose of 200 mg can be taken if needed on the first day Then, 200 mg 2 times a day as needed Children—Use and dose must be determined by your doctor For ankylosing spondylitis or osteoarthritis: Adults—200 milligrams (mg) once a day or 100 mg 2 times a day